Calorie Restriction Prevents Peripheral Nerve Damage

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Opalach K1, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L. Rejuvenation Res. 2010 Feb;13(1):65-74.  AbstractAging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous … Read more

Decreasing Calories 30% Increases Testosterone 21-27%

Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta). Sitzmann BD, Brown DI, Garyfallou VT, Kohama SG, Mattison JA, Ingram DK, Roth GS, Ottinger MA, Urbanski HF. Age (Dordr). 2014 Feb;36(1):183-97. Abstract:We previously reported that moderate calorie restriction (CR) has minimal impact on testicular gene expression in … Read more

Caloric Restriction Decreases Muscle Cell Death with Age

Sarcopenia: the role of apoptosis and modulation by caloric restriction. Dirks Naylor AJ, Leeuwenburgh C. Exerc Sport Sci Rev. 2008 Jan;36(1):19-24. AbstractThe mechanisms of sarcopenia have been slowly unraveled and likely involve activation of apoptosis. It is hypothesized that caloric restriction may, in part, attenuate sarcopenia by affecting apoptotic signaling. The signaling pathways responsible for … Read more