Intermittent Fasting, BDNF, Depression, More

Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. Duan W, Lee J, Guo Z, Mattson MP. J Mol Neurosci. 2001 Feb;16(1):1-12. [FREE FULL TEXT] Abstract Dietary restriction (DR) increases the lifespan of rodents and increases their resistance to several different age-related diseases including cancer and diabetes. Beneficial effects … Read more

Weight Loss, Set Point Theory, Metabolism and Thyroid Hormone

Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Weinsier RL, Nagy TR, Hunter GR, Darnell BE, Hensrud DD, Weiss HL. Am J Clin Nutr. 2000 Nov;72(5):1088-94. [FREE FULL TEXT] From the study: Abstract BACKGROUND: Obese persons generally regain lost weight, suggesting that adaptive metabolic changes favor return … Read more

Intermittent Fasting Maintains Muscle when Dieting

Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Varady KA. Obes Rev. 2011 Jul;12(7):e593-601. [FREE FULL TEXT] Abstract Dietary restriction is an effective strategy for weight loss in obese individuals. The most common form of dietary restriction implemented is daily calorie restriction (CR), which involves reducing energy by 15-60% … Read more

Short Term Fasting Increases Metabolic Rate

Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine. Zauner C, Schneeweiss B, Kranz A, Madl C, Ratheiser K, Kramer L, Roth E, Schneider B, Lenz K. Am J Clin Nutr. 2000 Jun;71(6):1511-5. [free full text] Abstract BACKGROUND: The effects of food restriction on energy metabolism have been under … Read more

Calorie Restriction Prevents Peripheral Nerve Damage

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Opalach K1, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L. Rejuvenation Res. 2010 Feb;13(1):65-74.  Abstract Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral … Read more

Decreasing Calories 30% Increases Testosterone 21-27%

Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta). Sitzmann BD, Brown DI, Garyfallou VT, Kohama SG, Mattison JA, Ingram DK, Roth GS, Ottinger MA, Urbanski HF. Age (Dordr). 2014 Feb;36(1):183-97. Abstract: We previously reported that moderate calorie restriction (CR) has minimal impact on testicular gene expression … Read more

Caloric Restriction Decreases Muscle Cell Death with Age

Sarcopenia: the role of apoptosis and modulation by caloric restriction. Dirks Naylor AJ, Leeuwenburgh C. Exerc Sport Sci Rev. 2008 Jan;36(1):19-24. Abstract The mechanisms of sarcopenia have been slowly unraveled and likely involve activation of apoptosis. It is hypothesized that caloric restriction may, in part, attenuate sarcopenia by affecting apoptotic signaling. The signaling pathways responsible … Read more

Eat Less for More Muscle?

Always looking for something for nothing, this might be the ultimate. When I was a competitive bodybuilder and weightlifter I was always force feeding myself to gain weight and compete in higher weight classes, and as fun as that sounds it gets old. In the last few years I had been vaguely following the results … Read more