Intermittent Fasting, BDNF, Depression, More

Dietary restriction stimulates BDNF production in the brain and thereby protects neurons against excitotoxic injury. Duan W, Lee J, Guo Z, Mattson MP. J Mol Neurosci. 2001 Feb;16(1):1-12. [FREE FULL TEXT] Abstract Dietary restriction (DR) increases the lifespan of rodents and increases their resistance to several different age-related diseases including cancer and diabetes. Beneficial effects … Read more

Exercise vs Intermittent Fasting for Longevity

Differential effects of intermittent feeding and voluntary exercise on body weight and lifespan in adult rats. Goodrick CL, Ingram DK, Reynolds MA, Freeman JR, Cider NL. J Gerontol. 1983 Jan;38(1):36-45. Abstract Male wistar rats were housed in laboratory cages or activity-wheel cages at eight 10.5 or 18 months of age. Part of each cage group … Read more

Weight Loss, Set Point Theory, Metabolism and Thyroid Hormone

Do adaptive changes in metabolic rate favor weight regain in weight-reduced individuals? An examination of the set-point theory. Weinsier RL, Nagy TR, Hunter GR, Darnell BE, Hensrud DD, Weiss HL. Am J Clin Nutr. 2000 Nov;72(5):1088-94. [FREE FULL TEXT] From the study: Abstract BACKGROUND: Obese persons generally regain lost weight, suggesting that adaptive metabolic changes favor return … Read more

Intermittent Fasting and Circadian Rhythms

I had a blog idea comparing various cleansing/detoxification schemes with intermittent fasting, with the gist being that there are some similarities. Both probably make you feel better for largely the same reasons, but that fasting is better and free. With detoxing and cleansing, it seems that someone is always trying to separate you from your … Read more

Creatine and Weight Training for Older Adults

Creatine supplementation during resistance training in older adults-a meta-analysis. Devries MC, Phillips SM. Med Sci Sports Exerc. 2014 Jun;46(6):1194-203. Abstract INTRODUCTION: Age-related sarcopenia and dynapenia have negative effects on strength and the ability to perform activities of daily living. Resistance training (RT) increases muscle mass and strength in older adults and is an established countermeasure … Read more

Coffee & Tea: How Much is Healthy?  

Coffee and tea: perks for health and longevity? Bhatti SK1, O’Keefe JH, Lavie CJ. Curr Opin Clin Nutr Metab Care. 2013 Nov;16(6):688-97. [FREE FULL TEXT] From the Abstract: RECENT FINDINGS: Tea consumption, especially green tea, is associated with significantly reduced risks for stroke, diabetes, depression, and improved levels of glucose, cholesterol, abdominal obesity and blood pressure. … Read more

Intermittent Fasting Maintains Muscle when Dieting

Intermittent versus daily calorie restriction: which diet regimen is more effective for weight loss? Varady KA. Obes Rev. 2011 Jul;12(7):e593-601. [FREE FULL TEXT] Abstract Dietary restriction is an effective strategy for weight loss in obese individuals. The most common form of dietary restriction implemented is daily calorie restriction (CR), which involves reducing energy by 15-60% … Read more

Alcohol Dose and Mortality (Remedy or Poison?)

Alcohol dosing and total mortality in men and women: an updated meta-analysis of 34 prospective studies. Arch Intern Med. 2006 Dec 11-25;166(22):2437-45. Di Castelnuovo A, Costanzo S, Bagnardi V, Donati MB, Iacoviello L, de Gaetano G. [FREE FULL TEXT] Abstract BACKGROUND: Moderate consumption of alcohol is inversely related with coronary disease, but its association with … Read more

Alcohol Fights Fat (in moderation)

Alcohol consumption, weight gain, and risk of becoming overweight in middle-aged and older women. Wang L, Lee IM, Manson JE, Buring JE, Sesso HD. Arch Intern Med. 2010 Mar 8;170(5):453-61. [FREE FULL TEXT] Abstract BACKGROUND: The obesity epidemic is a major health problem in the United States. Alcohol consumption is a source of energy intake that may … Read more

Anorexia: Light Weightlifting is all but Worthless

Does resistance training improve the functional capacity and well being of very young anorexic patients? A randomized controlled trial. del Valle MF, Pérez M, Santana-Sosa E, Fiuza-Luces C, Bustamante-Ara N, Gallardo C, Villaseñor A, Graell M, Morandé G, Romo GR, López-Mojares LM,Ruiz JR, Lucía A. J Adolesc Health. 2010 Apr;46(4):352-8. Abstract PURPOSE: We determined the … Read more

Vegans vs Lacto-Ovo vs Pescetarians

Mortality in vegetarians and nonvegetarians: detailed findings from a collaborative analysis of 5 prospective studies. Key TJ, Fraser GE, Thorogood M, Appleby PN, Beral V, Reeves G, Burr ML, Chang-Claude J, Frentzel-Beyme R, Kuzma JW, Mann J, McPherson K. Am J Clin Nutr. 1999 Sep;70(3 Suppl):516S-524S. [FREE FULL TEXT] Abstract We combined data from 5 … Read more

Intense Strength Training for Anorexia, Works Great!

Resistance training enhances muscular performance in patients with anorexia nervosa: a randomized controlled trial. Fernandez-del-Valle M, Larumbe-Zabala E, Villaseñor-Montarroso A, Cardona Gonzalez C, Diez-Vega I, Lopez Mojares LM, Perez Ruiz M. International Journal of Eating Disorders 2014 Sep;47(6):601-9. From the Abstract METHODS: From a total of 36 female patients with AN-R, one group (intervention, n = 18) underwent … Read more

Short Term Fasting Increases Metabolic Rate

Resting energy expenditure in short-term starvation is increased as a result of an increase in serum norepinephrine. Zauner C, Schneeweiss B, Kranz A, Madl C, Ratheiser K, Kramer L, Roth E, Schneider B, Lenz K. Am J Clin Nutr. 2000 Jun;71(6):1511-5. [free full text] Abstract BACKGROUND: The effects of food restriction on energy metabolism have been under … Read more

Intermittent Fasting (16/8) Improves Stroke Recovery

Intermittent fasting attenuates increases in neurogenesis after ischemia and reperfusion and improves recovery. Manzanero S, Erion JR, Santro T, Steyn FJ, Chen C, Arumugam TV, Stranahan AM. J Cereb Blood Flow Metab. 2014 May;34(5):897-905 [FREE FULL TEXT] Abstract Intermittent fasting (IF) is neuroprotective across a range of insults, but the question of whether extending the … Read more

Calorie Restriction Prevents Peripheral Nerve Damage

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Opalach K1, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L. Rejuvenation Res. 2010 Feb;13(1):65-74.  Abstract Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral … Read more

Decreasing Calories 30% Increases Testosterone 21-27%

Impact of moderate calorie restriction on testicular morphology and endocrine function in adult rhesus macaques (Macaca mulatta). Sitzmann BD, Brown DI, Garyfallou VT, Kohama SG, Mattison JA, Ingram DK, Roth GS, Ottinger MA, Urbanski HF. Age (Dordr). 2014 Feb;36(1):183-97. Abstract: We previously reported that moderate calorie restriction (CR) has minimal impact on testicular gene expression … Read more

Caloric Restriction Decreases Muscle Cell Death with Age

Sarcopenia: the role of apoptosis and modulation by caloric restriction. Dirks Naylor AJ, Leeuwenburgh C. Exerc Sport Sci Rev. 2008 Jan;36(1):19-24. Abstract The mechanisms of sarcopenia have been slowly unraveled and likely involve activation of apoptosis. It is hypothesized that caloric restriction may, in part, attenuate sarcopenia by affecting apoptotic signaling. The signaling pathways responsible … Read more