Calorie Restriction Prevents Peripheral Nerve Damage

Lifelong calorie restriction alleviates age-related oxidative damage in peripheral nerves. Opalach K1, Rangaraju S, Madorsky I, Leeuwenburgh C, Notterpek L. Rejuvenation Res. 2010 Feb;13(1):65-74. 

Abstract
Aging is associated with protein damage and imbalance in redox status in a variety of cells and tissues, yet little is known about the extent of age-related oxidative stress in the peripheral nervous system. Previously, we showed a drastic decline in the expression of glial and neuronal proteins in myelinated peripheral nerves with age, which is significantly ameliorated by lifelong calorie restriction. The age-related decline in functional molecules is associated with alterations in cellular protein homeostatic mechanisms, which could lead to a buildup of damaged, aggregated proteins. To determine the extent of oxidative damage within myelinated peripheral nerves, we studied sciatic nerves from rats of four different ages (8, 18, 29, and 38 months) maintained on an ad libitum or a 40% calorie-restricted diet. We found a prominent accumulation of polyubiquitinated substrates with age, which are associated with the conglomeration of distended lysosomes and lipofuscin adducts. The occurrence of these structures is notably less frequent within nerves of age-matched rodents kept on a lifelong reduced calorie diet. Markers for lipid peroxidation, inflammation, and immune cell infiltration are all elevated in nerves of ad libitum-fed rats, whereas food restriction is able to attenuate such deleterious processes with age. Together these results show that dietary restriction is an efficient means of defying age-related oxidative damage and maintaining a younger state in peripheral nerves.

My comments:

I love an article where I can link free full text and this one is worth clicking on just to see the graphs with the difference in peripheral nerve oxidative damage with age being DRAMATICALLY less with caloric restriction. The rats in this study were on lifelong calorie restriction which is a limitation as most people have eating a lot of calories, for a long time, before they start worrying about peripheral nerve damage issues like carpal tunnel syndrome, neuropathy or intermittent claudication. It also makes me wonder if there are benefits for those with sciatica.

I thought this article was an interesting follow up after seeing the study showing that caloric restriction attenuates muscle loss with age. I have had really, really good results treating my physical therapy patients with neuropathy from the outside with electric stimulation (based on what’s becoming a fair amount of research). Ditto for intermittent claudication. So this study makes me wonder if and how much the improvements might be further enhanced by treating the body/nerves from the inside with caloric restriction or intermittent fasting diets. Though this study found caloric restriction effective, another one I looked at suggests that intermittent fasting (which may or may not also entail caloric restriction) may be better still, specifically for protecting neurons from insult. Based on piles of studies I have on caloric restriction and intermittent fasting the big side effects are just that you stay healthier, age slower, and live longer. Like research on exercise, caloric restriction appears to be pretty much win win all the way around.

Thanks for reading my blog. If you have any questions or comments (even hostile ones) please don’t hesitate to ask/share. If you’re reading one of my older blogs, perhaps unrelated to neck or back pain, and it helps you, please remember Spinal Flow Yoga for you or someone you know in the future.


Chad Reilly is a Physical Therapist, obtaining his Master’s in Physical Therapy from Northern Arizona University. He graduated Summa Cum Laude with a B.S. Exercise Science also from NAU. He is a Certified Strength and Conditioning Specialist, and holds a USA Weightlifting Club Coach Certification as well as a NASM Personal Training Certificate. Chad completed his Yoga Teacher Training at Sampoorna Yoga in Goa, India.

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This is one of my older “legacy” blogs from my prior physical therapy site. If the information you find here seems only moderately related, or a bit technical for yoga, it’s because I wrote it with a different, but still overlapping, audience in mind. However, I think each blog does showcase my thought processes and research base, both of which very much influenced what evolved into Spinal Flow Yoga®.

Further, given that spine pain has long been a favorite topic of mine, much of the content within these older blogs will be directly relevant to Spinal Flow® even if at times I criticized yoga. In fact, that’s why I created Spinal Flow Yoga®, to correct what were, and still are, many physical problems in modern yoga sequences. Time permitting, I may revisit some of my favorites blogs add some content relating them to newer Spinal Flow® concepts that aim to cure neck and back pain as well as improve overall health and fitness from the comfort of your own home without the need for equipment. Hopefully that will make more sense out of why this blog is here. And if you have neck or back pain, you're in luck. Before you needed a gym to utilize my methods, but I've been working hard, gearing it towards home training, and efficiency and effectiveness have been remarkable. Hit the button to learn more about SC5 and SF5, my 5-minute flows, both of which I'm very proud of.